Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.
Identifieur interne : 000E85 ( Main/Exploration ); précédent : 000E84; suivant : 000E86Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.
Auteurs : Simon J G. Lewis [Australie] ; James M. Shine ; Shantel Duffy ; Glenda Halliday ; Sharon L. NaismithSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Aspartic Acid (analogs & derivatives), Aspartic Acid (metabolism), Case-Control Studies, Cognition Disorders (etiology), Cognition Disorders (pathology), Creatine (metabolism), Female, Gyrus Cinguli (metabolism), Humans, Linear Models, Magnetic Resonance Spectroscopy, Male, Mental Disorders (etiology), Mental Disorders (pathology), Mental Status Schedule, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications).
- MESH :
- chemical , analogs & derivatives : Aspartic Acid.
- chemical , metabolism : Aspartic Acid, Creatine.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Mental Disorders.
- metabolism : Gyrus Cinguli.
- pathology : Cognition Disorders, Mental Disorders.
- Aged, Case-Control Studies, Female, Humans, Linear Models, Magnetic Resonance Spectroscopy, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests.
Abstract
Patients with advanced Parkinson's disease (PD) commonly suffer with significant executive dysfunction and concomitant visual hallucinations. Although the underlying pathophysiology remains poorly understood, numerous studies have highlighted the strong association between these neuropsychiatric features, suggesting common neural pathways. Although previous neuroimaging studies have identified widespread volume loss across a number of cortical regions, to date, no studies have utilized proton magnetic resonance spectroscopy to provide insights into how neurometabolic changes may relate to such symptoms. Twenty patients with PD and 20 healthy controls underwent spectroscopy to determine the N-acetyl aspartate/creatine (NAA/Cr) ratio, which reflects the degree of neuronal integrity in neurodegenerative diseases. Voxels were obtained from the anterior cingulate cortex (ACC), an area critical for a wide range of executive mechanisms as well as from a control volume in the posterior cingulate cortex (PCC). Compared to controls, patients with PD had lower NAA/Cr ratios in the ACC. In turn, lower NAA/Cr ratios significantly correlated with poorer executive function on tasks of attentional set-shifting and response inhibition, as well as more-severe psychotic symptoms and poorer performance on the Bistable Percept Paradigm, a neuropsychological probe of visual hallucinations. NAA/Cr ratios were significantly lower in hallucinators, compared to nonhallucinators, within the ACC, but did not differ in the PCC. These results suggest that loss of neuronal integrity within the ACC plays an important role in the pathophysiology underlying executive functioning and visual hallucinations in PD. © 2012 Movement Disorder Society.
DOI: 10.1002/mds.25104
PubMed: 22865474
Affiliations:
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Shine</name></author><author><name sortKey="Duffy, Shantel" sort="Duffy, Shantel" uniqKey="Duffy S" first="Shantel" last="Duffy">Shantel Duffy</name></author><author><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25104</idno><idno type="RBID">pubmed:22865474</idno><idno type="pmid">22865474</idno><idno type="wicri:Area/PubMed/Corpus">000C88</idno><idno type="wicri:Area/PubMed/Curation">000C88</idno><idno type="wicri:Area/PubMed/Checkpoint">000F43</idno><idno type="wicri:Area/Ncbi/Merge">003758</idno><idno type="wicri:Area/Ncbi/Curation">003758</idno><idno type="wicri:Area/Ncbi/Checkpoint">003758</idno><idno type="wicri:Area/Main/Merge">000F33</idno><idno type="wicri:Area/Main/Curation">000E85</idno><idno type="wicri:Area/Main/Exploration">000E85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anterior cingulate integrity: executive and neuropsychiatric features in Parkinson's disease.</title><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J G" last="Lewis">Simon J G. Lewis</name><affiliation wicri:level="1"><nlm:affiliation>Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia. simonl@med.usyd.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Ageing Brain Center, Brain and Mind Research Institute, The University of Sydney, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M" last="Shine">James M. Shine</name></author><author><name sortKey="Duffy, Shantel" sort="Duffy, Shantel" uniqKey="Duffy S" first="Shantel" last="Duffy">Shantel Duffy</name></author><author><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aspartic Acid (analogs & derivatives)</term><term>Aspartic Acid (metabolism)</term><term>Case-Control Studies</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (pathology)</term><term>Creatine (metabolism)</term><term>Female</term><term>Gyrus Cinguli (metabolism)</term><term>Humans</term><term>Linear Models</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Mental Disorders (etiology)</term><term>Mental Disorders (pathology)</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Aspartic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid</term><term>Creatine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gyrus Cinguli</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with advanced Parkinson's disease (PD) commonly suffer with significant executive dysfunction and concomitant visual hallucinations. Although the underlying pathophysiology remains poorly understood, numerous studies have highlighted the strong association between these neuropsychiatric features, suggesting common neural pathways. Although previous neuroimaging studies have identified widespread volume loss across a number of cortical regions, to date, no studies have utilized proton magnetic resonance spectroscopy to provide insights into how neurometabolic changes may relate to such symptoms. Twenty patients with PD and 20 healthy controls underwent spectroscopy to determine the N-acetyl aspartate/creatine (NAA/Cr) ratio, which reflects the degree of neuronal integrity in neurodegenerative diseases. Voxels were obtained from the anterior cingulate cortex (ACC), an area critical for a wide range of executive mechanisms as well as from a control volume in the posterior cingulate cortex (PCC). Compared to controls, patients with PD had lower NAA/Cr ratios in the ACC. In turn, lower NAA/Cr ratios significantly correlated with poorer executive function on tasks of attentional set-shifting and response inhibition, as well as more-severe psychotic symptoms and poorer performance on the Bistable Percept Paradigm, a neuropsychological probe of visual hallucinations. NAA/Cr ratios were significantly lower in hallucinators, compared to nonhallucinators, within the ACC, but did not differ in the PCC. These results suggest that loss of neuronal integrity within the ACC plays an important role in the pathophysiology underlying executive functioning and visual hallucinations in PD. © 2012 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Duffy, Shantel" sort="Duffy, Shantel" uniqKey="Duffy S" first="Shantel" last="Duffy">Shantel Duffy</name><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M" last="Shine">James M. Shine</name></noCountry><country name="Australie"><noRegion><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J G" last="Lewis">Simon J G. 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